The Gupta Laboratory studied the mechanisms that generate and maintain cellular diversity in adult tissues, and how subversion of these mechanisms contributes to cancer. The group also investigated the genetic and cellular processes that govern adult and cancer stem cell self-renewal and differentiation. Improved comprehension of these processes is of fundamental biological interest and would facilitate the development of therapies for cancer and a range of other diseases.

Dr. Gupta is co-founder of Verastem and Naveris and is currently working to develop his laboratory’s research for clinical use in the early diagnosis and monitoring of cancer.