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Zagorulya M, Yim L, Morgan DM, Edwards A, Torres-Mejia E, Momin N, McCreery CV, Zamora IL, Horton BL, Fox JG, Wittrup KD, Love JC, Spranger S. Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer. Immunity. 2023 Feb 14;56(2):386-405.e10. doi: 10.1016/j.immuni.2023.01.010. Epub 2023 Feb 2. PMID: 36736322
Zagorulya M, Spranger S. Once upon a prime: DCs shape cancer immunity. Trends Cancer. 2023 Feb;9(2):172-184. doi: 10.1016/j.trecan.2022.10.006. Epub 2022 Nov 7. PMID: 36357313
Kim B. Nguyen, Christopher J. Copeland, Coralie M. Backlund, Nory G. Klop-Packel, Tanaka Remba, Byungji Kim, Nishant K. Singh, Michael E. Birnbaum, Darrell J. Irvine, Stefani Spranger. Decoupled neoantigen cross-presentation in tumors with high intratumor heterogeneity reduces dendritic cell activation to limit anti-tumor immunity. bioRxiv 2022.12.16.520773; doi: https://doi.org/10.1101/2022.12.16.520773(Re- submitted to eLife)
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Naranjo S, Cabana CM, LaFave LM, Romero R, Shanahan SL, Bhutkar A, Westcott PMK, Schenkel JM, Ghosh A, Liao LZ, Del Priore I, Yang D, Jacks T. Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform. Genes Dev. 2022 Aug 1;36(15-16):936-949. doi: 10.1101/gad.349659.122. Epub 2022 Sep 29. PMID: 36175034 Free PMC article.
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Amini AP, Kirkpatrick JD, Wang CS, Jaeger AM, Su S, Naranjo S, Zhong Q, Cabana CM, Jacks T, Bhatia SN. Multiscale profiling of protease activity in cancer. Nat Commun. 2022 Oct 3;13(1):5745. doi: 10.1038/s41467-022-32988-5. PMID: 36192379 Free PMC article.
Warchol S, Krueger R, Nirmal AJ, Gaglia G, Jessup J, Ritch CC, Hoffer J, Muhlich J, Burger ML, Jacks T, Santagata S, Sorger PK, Pfister H. Visinity: Visual Spatial Neighborhood Analysis for Multiplexed Tissue Imaging Data. IEEE Trans Vis Comput Graph. 2023 Jan;29(1):106-116. doi: 10.1109/TVCG.2022.3209378. Epub 2022 Dec 16. PMID: 36170403 Free PMC article.
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She R, Fair T, Schaefer NK, Saunders RA, Pavlovic BJ, Weissman JS, Pollen AA. (2023). Comparative landscape of genetic dependencies in human and chimpanzee stem cells. Cell. 2023 Jul 6;186(14):2977-2994.e23. doi: 10.1016/j.cell.2023.05.043. Epub 2023 Jun 20. PMID: 37343560; PMCID: PMC10461406.
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Sankaran VG, Weissman JS, Zon LI. (2022). Cellular barcoding to decipher clonal dynamics in disease. Science. 2022 Oct 14;378(6616):eabm5874. doi: 10.1126/science.abm5874. Epub 2022 Oct 14. PMID: 36227997; PMCID: PMC10111813.
Wu D, Poddar A, Ninou E, Hwang E, Cole MA, Liu SJ, Horlbeck MA, Chen J, Replogle JM, Carosso GA, Eng NWL, Chang J, Shen Y, Weissman JS, Lim DA. (2022). Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells. Cell Genom. 2022 Nov 9;2(11):100177. doi: 10.1016/j.xgen.2022.100177. Epub 2022 Sep 14. PMID: 36381608; PMCID: PMC9648144.
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Hao, L., Zhao, R.T., Welch, N.L., Tan, E.K., Zhong, Q., Harzallah, N.S., Ngambenjawong, C., Fleming, H.E., Sabeti, P.C, and Bhatia, S.N. (2023). CRISPR- Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics Nature Nanotechnology, 18:798.
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2022
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Jerby-Arnon L, Neftel C, Shore ME, Weisman HR, Mathewson ND, McBride MJ, Haas B, Izar B, Volorio A, Boulay G, Cironi L, Richman AR, Broye LC, Gurski JM, Luo CC, Mylvaganam R, Nguyen L, Mei S, Melms JC, Georgescu C, Cohen O, Buendia-Buendia JE, Segerstolpe A, Sud M, Cuoco MS, Labes D, Gritsch S, Zollinger DR, Ortogero N, Beechem JM, Petur Nielsen G, Chebib I, Nguyen-Ngoc T, Montemurro M, Cote GM, Choy E, Letovanec I, Cherix S, Wagle N, Sorger PK, Haynes AB, Mullen JT, Stamenkovic I, Rivera MN, Kadoch C, Wucherpfennig KW, Rozenblatt-Rosen O, Suvà ML, Riggi N, Regev A. 2021. Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma. Nat Med 27:289–300.
Katsikis G, Collis JF, Knudsen SM, Agache V, Sader JE, Manalis SR. 2021. Inertial and viscous flywheel sensing of nanoparticles. Nat Commun.
Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, Vander Heiden MG, Stephanopoulos G. 2021. Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells. FEBS J.
Kirkpatrick JD, Soleimany AP, Dudani JS, Liu H-J, Lam HC, Priolo C, Henske EP, Bhatia SN. 2021. Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis. Eur Respir J.
Lambert AW, Weinberg RA. 2021. Linking EMT programmes to normal and neoplastic epithelial stem cells. Nat Rev Cancer 1–14.
Lien EC, Vander Heiden MG. 2021. Pancreatic β cells put the glutamine engine in reverse. Cell Metab 33:702–704.
Lien EC, Westermark AM, Zhang Y, Yuan C, Li Z, Lau AN, Sapp KM, Wolpin BM, Vander Heiden MG. 2021. Low glycaemic diets alter lipid metabolism to influence tumour growth. Nature 1–6.
Luengo A, Li Z, Gui DY, Sullivan LB, Zagorulya M, Do BT, Ferreira R, Naamati A, Ali A, Lewis CA, Thomas CJ, Spranger S, Matheson NJ, Vander Heiden MG. 2021. Increased demand for NAD+ relative to ATP drives aerobic glycolysis. Mol Cell.
Mueller HS, Fowler CE, Dalin S, Moiso E, Udomlumleart T, Garg S, Hemann MT, Lees JA. 2021. Acquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel. PNAS 118.
Pikman Y, Ocasio-Martinez N, Alexe G, Dimitrov B, Kitara S, Diehl FF, Robichaud AL, Conway AS, Ross L, Su A, Ling F, Qi J, Roti G, Lewis CA, Puissant A, Vander Heiden MG, Stegmaier K. 2021. Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy. Leukemia 1–13.
Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan S-L, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, Park JK, Burger ME, Rozenblatt-Rosen O, Cong L, Pauken KE, Regev A, Jacks T. 2021. Conventional type I dendric cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes. Immunity S1074-7613(21)00360–5.
Schmidt DR, Patel R, Kirsch DG, Lewis CA, Vander Heiden MG, Locasale JW. 2021. Metabolomics in cancer research and emerging applications in clinical oncology. CA: A Cancer Journal for Clinicians.
Soleimany AP, Kirkpatrick JD, Su S, Dudani JS, Zhong Q, Bekdemir A, Bhatia SN. 2021. Activatable Zymography Probes Enable In Situ Localization of Protease Dysregulation in Cancer. Cancer Res 81:213–224.
Su XA, Ma D, Parsons JV, Replogle JM, Amatruda JF, Whittaker CA, Stegmaier K, Amon A. 2021. RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress. Genes Dev.
Sullivan MR, Darnell AM, Reilly MF, Kunchok T, Joesch-Cohen L, Rosenberg D, Ali A, Rees MG, Roth JA, Lewis CA, Vander Heiden MG. 2021 Methionine synthase is essential for cancer cell proliferation in physiological folate environments. Nat Metab. 3(11):1500-1511.
Tian C, Huang Y, Clauser KR, Rickelt S, Lau AN, Carr SA, Vander Heiden MG, Hynes RO. 2021. Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells. Nature Communications 12:2328.
Trakala M, Aggarwal M, Sniffen C, Zasadil L, Carroll A, Ma D, Su XA, Wangsa D, Meyer A, Sieben CJ, Zhong J, Hsu P, Paradis G, Ried T, Holland A, Deursen JV, Amon A. 2021. Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis. Genes Dev 35:1079–1092.
Wang RW, Viganò S, Ben-David U, Amon A, Santaguida S. 2021. Aneuploid senescent cells activate NF-κB to promote their immune clearance by NK cells. EMBO Rep 22:e52032.
2020
Alkan HF, Vesely PW, Hackl H, Foßelteder J, Schmidt DR, Vander Heiden MG, Pichler M, Hoefler G, Bogner-Strauss JG. 2020. Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis. Cancer Metab 8:26.
Benjamin DC, Kang JH, Hamza B, King EM, Lamar JM, Manalis SR, Hynes RO. 2020. YAP Enhances Tumor Cell Dissemination by Promoting Intravascular Motility and Re-entry into Systemic Circulation. Cancer Res canres.0212.2020.
Boehnke N, Correa S, Hao L, Wang W, Straehla JP, Bhatia SN, Hammond PT. 2020. Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing. Angew Chem Int Ed Engl 59:2776–2783.
Bruno PM, Lu M, Dennis KA, Inam H, Moore CJ, Sheehe J, Elledge SJ, Hemann MT, Pritchard JR. 2020. The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning. Proc Natl Acad Sci U S A 117:4053–4060.
Buss CG, Bhatia SN. 2020. Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics. Proc Natl Acad Sci U S A 117:13428–13436.
Chatterjee N, Whitman MA, Harris CA, Min SM, Jonas O, Lien EC, Luengo A, Vander Heiden MG, Hong J, Zhou P, Hemann MT, Walker GC. 2020. REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. Proc Natl Acad Sci U S A 117:28918–28921.
Gupta M, Concepcion CP, Fahey CG, Keshishian H, Bhutkar A, Brainson CF, Sanchez-Rivera FJ, Pessina P, Kim JY, Simoneau A, Paschini M, Beytagh MC, Stanclift CR, Schenone M, Mani DR, Li C, Oh A, Li F, Hu H, Karatza A, Bronson RT, Shaw AT, Hata AN, Wong K-K, Zou L, Carr SA, Jacks T, Kim CF. 2020. BRG1 loss predisposes lung cancers to replicative stress and ATR dependency. Cancer Res 80.
Hebert JD, Myers SA, Naba A, Abbruzzese G, Lamar JM, Carr SA, Hynes RO. 2020a. Proteomic Profiling of the ECM of Xenograft Breast Cancer Metastases in Different Organs Reveals Distinct Metastatic Niches. Cancer Res 80:1475–1485.
Hebert JD, Tian C, Lamar JM, Rickelt S, Abbruzzese G, Liu X, Hynes RO. 2020b. The scaffold protein IQGAP1 is crucial for extravasation and metastasis. Sci Rep 10.
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Jin X, Demere Z, Nair K, Ali A, Ferraro GB, Natoli T, Deik A, Petronio L, Tang AA, Zhu C, Wang L, Rosenberg D, Mangena V, Roth J, Chung K, Jain RK, Clish CB, Vander Heiden MG, Golub TR. 2020. A metastasis map of human cancer cell lines. Nature 588:331–336.
Kang JH, Katsikis G, Li Z, Sapp KM, Stockslager MA, Lim D, Vander Heiden MG, Yaffe MB, Manalis SR, Miettinen TP. 2020. Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division. Nat Commun 11:4983.
Karthaus WR, Hofree M, Choi D, Linton EL, Turkekul M, Bejnood A, Carver B, Gopalan A, Abida W, Laudone V, Biton M, Chaudhary O, Xu T, Masilionis I, Manova K, Mazutis L, Pe’er D, Regev A, Sawyers CL. 2020. Regenerative potential of prostate luminal cells revealed by single-cell analysis. Science 368:497–505.
Kirkpatrick JD, Warren AD, Soleimany AP, Westcott PMK, Voog JC, Martin-Alonso C, Fleming HE, Tammela T, Jacks T, Bhatia SN. 2020. Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling. Sci Transl Med 12.
Lau AN, Li Z, Danai LV, Westermark AM, Darnell AM, Ferreira R, Gocheva V, Sivanand S, Lien EC, Sapp KM, Mayers JR, Biffi G, Chin CR, Davidson SM, Tuveson DA, Jacks T, Matheson NJ, Yilmaz O, Vander Heiden MG. 2020. Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma. eLife 9:e56782.
Lau AN, Vander Heiden MG. 2020. Metabolism in the Tumor Microenvironment. Annu Rev Cancer Biol 4:17–40.
Liu VM, Howell AJ, Hosios AM, Li Z, Israelsen WJ, Heiden MGV. 2020. Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity. FEBS Lett 594:646–664.
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Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, Rajasekhar VK, Kastenhuber ER, Bacha S, Sriram RK, Stein BD, Bakhoum SF, Snuderl M, Cotzia P, Healey JH, Mainolfi N, Suri V, Friedman A, Manfredi M, Sabatini DM, Jones DR, Yu M, Zhao JJ, Jain RK, Keshari KR, Davies MA, Heiden MGV, Hernando E, Mann M, Cantley LC, Pacold ME. 2020. Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer Discov 10:1352–1373.
Replogle JM, Zhou W, Amaro AE, McFarland JM, Villalobos-Ortiz M, Ryan J, Letai A, Yilmaz O, Sheltzer J, Lippard SJ, Ben-David U, Amon A. 2020. Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division. Proc Natl Acad Sci USA 117:30566–30576.
Rickelt S, Condon C, Mana M, Whittaker C, Pfirschke C, Roper J, Patil DT, Brown I, Mattia AR, Zukerberg L, Zhao Q, Chetty R, Lauwers GY, Neyaz A, Leijssen LGJ, Boylan K, Yilmaz OH, Deshpande V, Hynes RO. 2020. Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions. Clin Cancer Res 26:1277–1287.
Romero R, Sánchez-Rivera FJ, Westcott PMK, Mercer KL, Bhutkar A, Muir A, González Robles TJ, Lamboy Rodríguez S, Liao LZ, Ng SR, Li L, Colón CI, Naranjo S, Beytagh MC, Lewis CA, Hsu PP, Bronson RT, Vander Heiden MG, Jacks T. 2020. Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1. Nature Cancer 1:589–602.
Schuerle S, Furubayashi M, Soleimany AP, Gwisai T, Huang W, Voigt C, Bhatia SN. 2020. Genetic Encoding of Targeted Magnetic Resonance Imaging Contrast Agents for Tumor Imaging. ACS Synth Biol 9:392–401.
Sivanand S, Vander Heiden MG. 2020. Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer. Cancer Cell 37:147–156.
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Soleimany AP, Kirkpatrick JD, Su S, Dudani JS, Zhong Q, Bekdemir A, Bhatia SN. 2020. Activatable zymography probes enable in situ localization of protease dysregulation in cancer. Cancer Res.
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Tian C, Öhlund D, Rickelt S, Lidström T, Huang Y, Hao L, Zhao RT, Franklin O, Bhatia SN, Tuveson DA, Hynes RO. 2020. Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma. Cancer Res 80:1461–1474.
Urbanska M, Muñoz HE, Shaw Bagnall J, Otto O, Manalis SR, Di Carlo D, Guck J. 2020. A comparison of microfluidic methods for high-throughput cell deformability measurements. Nat Methods 17:587–593.
van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, Haigis MC, Scadden DT. 2020. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metabolism 32:391-403.e6.
Vassel F-M, Bian K, Walker GC, Hemann MT. 2020. Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer. Proc Natl Acad Sci U S A.
Zhang S, Iyer S, Ran H, Dolgalev I, Gu S, Wei W, Foster CJR, Loomis CA, Olvera N, Dao F, Levine DA, Weinberg RA, Neel BG. 2020. Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer. Cancer Discov.
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2019
Babic A, Rosenthal MH, Bamlet WR, Takahashi N, Sugimoto M, Danai LV, Morales-Oyarvide V, Khalaf N, Dunne RF, Brais LK, Welch MW, Zellers CL, Dennis C, Rifai N, Prado CM, Caan B, Sundaresan TK, Meyerhardt JA, Kulke MH, Clish CB, Ng K, Heiden MGV, Petersen GM, Wolpin BM. 2019. Post diagnosis loss of skeletal muscle, but not adipose tissue, is associated with shorter survival of patients with advanced pancreatic cancer. Cancer Epidemiol Biomarkers Prev cebp.0370.2019.
Cheng C-W, Biton M, Haber AL, Gunduz N, Eng G, Gaynor LT, Tripathi S, Calibasi-Kocal G, Rickelt S, Butty VL, Moreno-Serrano M, Iqbal AM, Bauer-Rowe KE, Imada S, Ulutas MS, Mylonas C, Whary MT, Levine SS, Basbinar Y, Hynes RO, Mino-Kenudson M, Deshpande V, Boyer LA, Fox JG, Terranova C, Rai K, Piwnica-Worms H, Mihaylova MM, Regev A, Yilmaz ÖH. 2019. Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet. Cell 178:1115-1131.e15.
Dalin S, Sullivan MR, Lau AN, Grauman-Boss B, Mueller HS, Kreidl E, Fenoglio S, Luengo A, Lees JA, Heiden MGV, Lauffenburger DA, Hemann MT. 2019. Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance. Cancer Res 79:5723–5733.
Derynck R, Weinberg RA. 2019. EMT and Cancer: More Than Meets the Eye. Developmental Cell 49:313–316.
Diehl FF, Lewis CA, Fiske BP, Vander Heiden MG. 2019. Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation. Nat Metab 1:861–867.
Dongre A, Weinberg RA. 2019. New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol 20:69–84.
Hamza B, Ng SR, Prakadan SM, Delgado FF, Chin CR, King EM, Yang LF, Davidson SM, DeGouveia KL, Cermak N, Navia AW, Winter PS, Drake RS, Tammela T, Li CM-C, Papagiannakopoulos T, Gupta AJ, Shaw Bagnall J, Knudsen SM, Vander Heiden MG, Wasserman SC, Jacks T, Shalek AK, Manalis SR. 2019. Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer. Proc Natl Acad Sci U S A 116:2232–2236.
Jailkhani N, Ingram JR, Rashidian M, Rickelt S, Tian C, Mak H, Jiang Z, Ploegh HL, Hynes RO. 2019. Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix. Proc Natl Acad Sci U S A 116:14181–14190.
Jain PK, Lo JH, Rananaware S, Downing M, Panda A, Tai M, Raghavan S, Fleming HE, Bhatia SN. 2019. Non-viral delivery of CRISPR/Cas9 complex using CRISPR-GPS nanocomplexes. Nanoscale 11:21317–21323.
Kang JH, Miettinen TP, Chen L, Olcum S, Katsikis G, Doyle PS, Manalis SR. 2019. Non-invasive monitoring of single-cell mechanics by acoustic scattering. Nat Methods 16:263–269.
Lamar JM, Xiao Y, Norton E, Jiang Z-G, Gerhard GM, Kooner S, Warren JSA, Hynes RO. 2019. SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis. J Biol Chem 294:2302–2317.
Li L, Ng SR, Colón CI, Drapkin BJ, Hsu PP, Li Z, Nabel CS, Lewis CA, Romero R, Mercer KL, Bhutkar A, Phat S, Myers DT, Muzumdar MD, Westcott PMK, Beytagh MC, Farago AF, Heiden MGV, Dyson NJ, Jacks T. 2019. Identification of DHODH as a therapeutic target in small cell lung cancer. Sci Transl Med 11.
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Loynachan C, Soleimany AP, Dudani JS, Lin Y, Najer A, Bekdemir A, Chen Q, Bhatia SN, Stevens M. 2019. Renal clearable catalytic gold nanoclusters for in vivo disease monitoring. Nat Nanotech 883–890.
Mattaini KR, Sullivan MR, Lau AN, Fiske BP, Bronson RT, Vander Heiden MG. 2019. Increased PHGDH expression promotes aberrant melanin accumulation. BMC Cancer 19.
Neftel C, Laffy J, Filbin MG, Hara T, Shore ME, Rahme GJ, Richman AR, Silverbush D, Shaw ML, Hebert CM, Dewitt J, Gritsch S, Perez EM, Castro LNG, Lan X, Druck N, Rodman C, Dionne D, Kaplan A, Bertalan MS, Small J, Pelton K, Becker S, Bonal D, Nguyen Q-D, Servis RL, Fung JM, Mylvaganam R, Mayr L, Gojo J, Haberler C, Geyeregger R, Czech T, Slavc I, Nahed BV, Curry WT, Carter BS, Wakimoto H, Brastianos PK, Batchelor TT, Stemmer-Rachamimov A, Martinez-Lage M, Frosch MP, Stamenkovic I, Riggi N, Rheinbay E, Monje M, Rozenblatt-Rosen O, Cahill DP, Patel AP, Hunter T, Verma IM, Ligon KL, Louis DN, Regev A, Bernstein BE, Tirosh I, Suvà ML. 2019. An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. Cell 178:835-849.e21.
Rashidian M, LaFleur MW, Verschoor VL, Dongre A, Zhang Y, Nguyen TH, Kolifrath S, Aref AR, Lau CJ, Paweletz CP, Bu X, Freeman GJ, Barrasa MI, Weinberg RA, Sharpe AH, Ploegh HL. 2019. Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade. Proc Natl Acad Sci U S A 116:16971–16980.
Schmidt L, Eskiocak B, Kohn R, Dang C, Joshi NS, DuPage M, Lee D-Y, Jacks T. 2019. Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation. Proc Natl Acad Sci U S A 116:17460–17469.
Shibue T, Reinhardt F, Weinberg RA. 2019. Syndecan-Mediated Ligation of ECM Proteins Triggers Proliferative Arrest of Disseminated Tumor Cells. Cancer Res 79:5944–5957.
Struntz NB, Chen A, Deutzmann A, Wilson RM, Stefan E, Evans HL, Ramirez MA, Liang T, Caballero F, Wildschut MHE, Neel DV, Freeman DB, Pop MS, McConkey M, Muller S, Curtin BH, Tseng H, Frombach KR, Butty VL, Levine SS, Feau C, Elmiligy S, Hong JA, Lewis TA, Vetere A, Clemons PA, Malstrom SE, Ebert BL, Lin CY, Felsher DW, Koehler AN. 2019. Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription. Cell Chem Biol 26:711-723.e14.
Sullivan Mark R, Danai LV, Lewis CA, Chan SH, Gui DY, Kunchok T, Dennstedt EA, Vander Heiden MG, Muir A. 2019. Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability. eLife 8:e44235.
Sullivan Mark R., Mattaini KR, Dennstedt EA, Nguyen AA, Sivanand S, Reilly MF, Meeth K, Muir A, Darnell AM, Bosenberg MW, Lewis CA, Vander Heiden MG. 2019. Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting. Cell Metabolism 29:1410-1421.e4.
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2018
Alkan HF, Walter KE, Luengo A, Madreiter-Sokolowski CT, Stryeck S, Lau AN, Al-Zoughbi W, Lewis CA, Thomas CJ, Hoefler G, et al. 2018. Cytosolic aspartate availability determines cell survival when glutamine is limiting. Cell Metab 28: 706-720.e6.
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Danai LV, Babic A, Rosenthal MH, Dennstedt EA, Muir A, Lien EC, Mayers JR, Tai K, Lau AN, Jones-Sali P, et al. 2018. Altered exocrine function can drive adipose wasting in early pancreatic cancer. Nature 558: 600–604.
Dayton TL, Gocheva V, Miller KM, Bhutkar A, Lewis CA, Bronson RT, Vander Heiden MG, Jacks T. 2018. Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma. Cancer Metab 6.
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2017
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2016
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2015
Danino T, Prindle A, Kwong GA, Skalak M, Li H, Allen K, Hasty J, Bhatia SN. 2015. Programmable probiotics for detection of cancer in urine. Sci Transl Med 7: 289ra84.
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2014
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Labelle M, Begum S, Hynes RO. 2014. Platelets guide the formation of early metastatic niches. Proc Natl Acad Sci U S A 111: E3053–E3061.
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2013
Shibue T, Brooks MW, Weinberg RA. 2013. An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell 24: 481–498.
2012
Labelle M, Hynes RO. 2012. The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov 2: 1091–1099.
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2011
Gertler F, Condeelis J. 2011. Metastasis: tumor cells becoming Menacing. Trends Cell Biol 21: 81–90.
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2010
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