Research images: (L) The Hemann Lab has identified a series of genetic signatures that can be used to identify how drugs work and in which patients they might be effective. (R) The Lees Lab’s zebrafish models of uveal melanoma, a cancer of the eye with high propensity to metastasize, help researchers follow the origin and progression of this cancer.

The metastasis, or spread, of cancer is a multi-step cascade of events. Likewise, research from MIT’s Ludwig Center is addressed to multiple key biological and interventional junctures, uncovering biological mechanisms that can serve as novel biomarkers and targets, and developing sensitive detection methods and powerful therapeutic strategies. Discoveries and advances from the center help to both inform the cancer research field and expand the repertoire of clinical tools for improving patient outcomes.